Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DMT1 Maintains Iron Homeostasis to Regulate Mitochondrial Function in Porcine Oocytes.

Journal of cellular physiology·2024

Same author

miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.

Cell stress & chaperones·2023

Same author

SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.

International journal of molecular sciences·2022

Same author

Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.

Molecular biology reports·2022

Same author

Identification and bioinformatics analysis of differentially expressed milk exosomal microRNAs in milk exosomes of heat-stressed Holstein cows.

Functional & integrative genomics·2021

Same author

SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.

Cell death discovery·2021

Search research articles

Related Experiment Video

Updated: May 7, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

Prognostic value of preoperative systemic immune-inflammation index/albumin for patients with hepatocellular

Kun-Lin Chen¹, Yi-Wen Qiu¹, Ming Yang¹

¹Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

World Journal of Gastroenterology

|December 30, 2024

Summary

The systemic immune-inflammation index to albumin ratio (SII/ALB) can predict outcomes for hepatocellular carcinoma (HCC) patients after surgery. This ratio, combined with other factors in a nomogram, aids in HCC treatment decisions.

Keywords:

Hepatocellular carcinoma Inflammation Liver resection Prognosis Systemic immune-inflammation index/albumin

More Related Videos

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

Related Experiment Videos

Last Updated: May 7, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

Area of Science:

Hepatobiliary surgery
Surgical oncology
Cancer biomarkers

Background:

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide.
The prognostic value of systemic immune-inflammation index (SII) and albumin (ALB) is known individually, but their combined predictive power (SII/ALB) in HCC post-hepatectomy is unexplored.
A higher SII/ALB ratio is hypothesized to correlate with poorer overall survival (OS) and recurrence-free survival (RFS) in HCC patients.

Purpose of the Study:

To evaluate the preoperative SII/ALB ratio as a predictor of prognosis in HCC patients undergoing hepatectomy.
To develop and validate a nomogram incorporating SII/ALB for predicting HCC patient outcomes.

Main Methods:

Retrospective analysis of 1653 HCC patients who underwent curative hepatectomy (2014-2019).
Utilized Cox proportional hazards models and Kaplan-Meier curves to assess OS and RFS.
Developed a nomogram using least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox analysis, validated internally with ROC, DCA, and C-index.

Main Results:

The SII/ALB ratio independently predicted OS (HR=1.22, P=0.025) and RFS (HR=1.19, P=0.022) in HCC patients.
A nomogram incorporating SII/ALB, age, AFP, HBsAg, ALB-grade, tumor diameter, PVTT, and tumor number showed good predictive accuracy (C-index 0.73 training, 0.71 validation).
Nomogram performance was confirmed by high accuracy in ROC, DCA, and calibration analyses.

Conclusions:

The preoperative SII/ALB ratio is an independent predictor of outcomes for HCC patients undergoing curative surgical treatment.
The developed nomogram demonstrates high accuracy and clinical utility for aiding in HCC treatment decision-making.