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Caregiver Willingness to Participate in Pediatric Clinical Research During COVID-19

Crystal S Lim, Dustin E Sarver, Dustin C Brown

    Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners
    |December 30, 2024
    PubMed

    Insights

    Caregiver willingness to join pediatric clinical research varied by study type during COVID-19. Attitudes and location influenced participation, highlighting the need for ongoing research into vaccine hesitancy.

    Area of Science:

    • Pediatric clinical research
    • Public health
    • Epidemiology

    Background:

    • Understanding caregiver willingness to participate in pediatric clinical research is crucial.
    • Caregiver perceptions of pediatric clinical research during the COVID-19 pandemic were examined.
    • Research attitudes and sociodemographic factors were analyzed as predictors of willingness.

    Purpose of the Study:

    • To assess caregiver willingness to participate in different pediatric clinical research modalities during COVID-19.
    • To identify predictors of willingness, including research attitudes and geographic location.
    • To understand variations in willingness based on research focus (e.g., vaccine vs. non-vaccine).

    Main Methods:

    • A cross-sectional telephone survey was conducted with 600 caregivers of children.
    • Data were collected between August 2020 and April 2021.
    • Willingness to participate in telehealth, in-person, and vaccine-focused research was assessed.

    Main Results:

    • Caregivers showed greater willingness for non-vaccine research (64.0% telehealth, 59.4% in-person) compared to vaccine research (22.1%).
    • Predictors of willingness differed between rural and nonrural caregivers.
    • Specific research attitudes were identified as significant predictors of participation.

    Conclusions:

    • Caregiver willingness in pediatric clinical research during COVID-19 varied by modality and was influenced by research attitudes and geography.
    • Continued surveillance of pediatric vaccine and clinical research hesitancy is recommended.
    • Tailored approaches may be needed to enhance participation based on caregiver characteristics and location.
    Abstract

    Keywords:
    COVID-19CaregiversClinical researchFamilyVaccine developmentmRNA vaccines

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