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Updated: Jun 4, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB

Li Yang1, Xiao-Tao Zeng2, Rong-Hua Luo3

  • 1Department of Pulmonary and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China.

Virologica Sinica
|December 30, 2024
PubMed
Summary

Host proteins CRTC1, CRTC2, and CRTC3 inhibit human coronavirus (HCoV) replication by targeting the viral RNA-dependent RNA polymerase (RdRp). These CRTCs offer potential for developing new anti-HCoV therapies.

Keywords:
CREB-regulated transcription coactivator 3 (CRTC3)Cyclic AMP response element-binding protein (CREB)Human coronaviruses (HCoVs)RNA-Dependent RNA polymerase (RdRp)Virus replicationVirus-host interaction

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