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Related Experiment Videos

Jaborandi: an interdisciplinary appraisal.

B Holmstedt, S H Wassén, R E Schultes

    Journal of Ethnopharmacology
    |January 1, 1979
    PubMed
    Summary

    Jaborandi leaves, despite historical use, lacked specific South American Indian applications. Pilocarpine, discovered in 1875, is now crucial in ophthalmology.

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    Area of Science:

    • Pharmacology
    • Ethnobotany
    • Ophthalmology

    Background:

    • The vernacular name 'jaborandi' is applied to various plants, though Pilocarpus species are medically significant.
    • Historical ethnobotanical records mention Pilocarpus Jaborandi Holmes for diverse ailments, but specific indigenous uses remain unclear.

    Observation:

    • Introduction of jaborandi leaves to Western medicine in 1873 revealed potent diaphoretic and sialagogue effects.
    • The alkaloid pilocarpine was isolated in 1875, leading to widespread, albeit temporary, therapeutic applications.

    Findings:

    • Most historical uses of jaborandi leaves and pilocarpine have been discontinued.
    • Pilocarpine's miotic properties were recognized in ophthalmology by 1876.

    Implications:

    • Pilocarpine remains a vital component in ophthalmology, particularly in combination with physostigmine.
    • This highlights the enduring, albeit specialized, therapeutic value of natural products in modern medicine.

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