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AKR1B10 and digestive tumors development: a review
Yao Shen1, Ailin Qiu2, Xin Huang3,4
1Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Frontiers in Immunology
|December 31, 2024
Summary
Aldo-keto reductase family 1 member B10 (AKR1B10) shows promise as a biomarker for digestive system diseases. Research highlights its potential in diagnosing and treating various gastrointestinal cancers.
Area of Science:
- Biochemistry
- Oncology
- Gastroenterology
Background:
- Aldo-keto reductase family 1 member B10 (AKR1B10) is primarily cytoplasmic, with high expression in the stomach and intestines.
- Low or absent expression in other tissues makes AKR1B10 a potential biomarker for digestive system diseases.
Purpose of the Study:
- To review recent research on AKR1B10 in digestive system tumors over the past 5 years.
- To discuss current trends and future research directions for AKR1B10 in oncological and non-oncological diseases.
Main Methods:
- Literature review of studies published within the last 5 years.
- Analysis of AKR1B10 expression and its role in various digestive system cancers.
Main Results:
- AKR1B10 is implicated in hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma.
- Recent research highlights AKR1B10's potential as a diagnostic and therapeutic target.
Conclusions:
- AKR1B10 is a significant biomarker in digestive system tumors.
- Further research is warranted to explore AKR1B10's full potential in both cancer and non-cancerous conditions of the digestive system.
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