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Glycated hemoglobin A1c and cognitive impairment in complex chronic patients: A cross-sectional study

Jindan Zhang1, Yuqing Song1, Shuai Xu1

  • 1School of Nursing, Changchun University of Chinese Medicine, Changchun, Jilin, China.

Neuro Endocrinology Letters
|December 31, 2024
PubMed

Insights

Glycated hemoglobin A1c (HbA1c) did not significantly predict cognitive impairment in elderly patients with complex chronic conditions. This suggests HbA1c may not be an independent marker for cognitive decline in this vulnerable population.

Area of Science:

  • Gerontology
  • Endocrinology
  • Neurology

Background:

  • Cognitive impairment is a significant concern in elderly individuals with complex chronic conditions.
  • The relationship between Glycated hemoglobin A1c (HbA1c) and cognitive function in this population remains unclear.
  • Understanding predictors of cognitive decline is crucial for effective patient management.

Purpose of the Study:

  • To investigate the association between HbA1c levels and cognitive impairment.
  • To determine if HbA1c is an independent predictor of cognitive decline in elderly patients with complex chronic conditions.

Main Methods:

  • Cross-sectional study of 2,366 patients in Catalonia (2013-2017).
  • HbA1c levels from clinical records; cognitive function assessed via ICD-10 criteria and Pfeiffer test.
  • Multivariate logistic regression analysis with subgroup analyses, controlling for demographics, comorbidities, and medications.

Main Results:

  • The cohort averaged 84.1 years, with 20.2% experiencing cognitive impairment.
  • No significant association was found between HbA1c levels and cognitive impairment after adjusting for covariates (OR = 0.99, p > 0.05).
  • Interaction effects were observed with ischemic cardiomyopathy and Barthel scores.

Conclusions:

  • HbA1c levels were not significantly correlated with cognitive impairment in elderly patients with complex chronic conditions.
  • HbA1c may not serve as an independent predictor of cognitive decline in this specific patient group.
  • Further research is warranted to confirm these findings and explore other potential factors influencing cognitive health.
Abstract

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