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Symptom Patterns in Adults With Cyclic Vomiting Syndrome: A 6-Month Prospective Observational Study.
Yaozhu J Chen1, Danielle Rodriguez2, Camilla A Richmond1
1Takeda Development Center Americas Inc., Cambridge, Massachusetts, USA.
Neurogastroenterology and Motility
|December 31, 2024
Summary
Cyclic vomiting syndrome (CVS) episodes show significant variation in duration and frequency. This study highlights the need for better characterization of CVS symptom patterns and episodes.
Area of Science:
- Gastroenterology
- Gut-brain interaction disorders
Background:
- Limited data exists on the natural history and symptom patterns of cyclic vomiting syndrome (CVS).
- CVS is a gut-brain interaction disorder characterized by recurrent vomiting, retching, and nausea.
Purpose of the Study:
- To prospectively assess symptom patterns and natural history in adults with CVS.
- To characterize the heterogeneity of CVS episodes.
Main Methods:
- A 6-month observational study using remote electronic daily diaries.
- Adult patients with CVS recorded symptoms, severity, and episode details.
- CVS episodes were defined by specific daily vomiting and/or retching event thresholds.
Main Results:
- 94.6% of enrolled patients provided usable diary data; 69.3% experienced at least one CVS episode.
- A median of 0.6-0.7 episodes per 30 days were reported, with median durations of 2-3 days.
- 14.8% experienced interepisodic vomiting/retching, and non-vomiting symptoms like nausea and abdominal pain were more frequent during episodes.
Conclusions:
- CVS episodes exhibit marked heterogeneity in duration and associated symptoms.
- Further research is needed to refine the definition and characterization of CVS episodes.
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