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Using Functional Magnetic Resonance Imaging to Detect Differences in Micturition-Related Brain Activity Between

Nhi T Ha1, Aidin Abedi2, Luis Alejandro Morales Ojeda1,3,4

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Summary
This summary is machine-generated.

Voluntary detrusor contractions show greater brain activity in motor and sensory regions compared to involuntary ones, which are linked to urge urinary incontinence. This highlights differences in neuroactivation for bladder control.

Keywords:
fMRImicturitionneurogenic bladderstroke

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Area of Science:

  • Neuroscience
  • Urology
  • Functional Magnetic Resonance Imaging (fMRI)

Background:

  • Detrusor contractions are volitional or involuntary, with involuntary ones characteristic of urge urinary incontinence.
  • Understanding neuroactivation differences can reveal pathophysiology and therapeutic targets for lower urinary tract symptoms.

Purpose of the Study:

  • To compare brain activity (BOLD-signal fMRI) during voluntary and involuntary detrusor contractions in stroke survivors with lower urinary tract symptoms.

Main Methods:

  • Simultaneous urodynamics and BOLD-signal fMRI were used in 27 stroke survivors over four filling cycles.
  • Contractions were classified as voluntary (within 10s of voiding instruction) or involuntary.
  • Brain activity was analyzed across contraction phases (Early, Rise, Plateau, Fall) with specific statistical thresholds.

Main Results:

  • Involuntary detrusor contractions showed diminished brain activity compared to volitional ones across all phases.
  • Differences were most pronounced in sensory and autonomic areas during the Early phase, shifting to motor control regions later.

Conclusions:

  • Volitional contractions engaged motor, sensory, and executive functioning brain regions more than involuntary ones.
  • Findings suggest volitional contractions involve higher-level processing, while involuntary contractions may be driven by subcortical reflexes.