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The current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids with

Zhi Xu1, Rongqiang Li2, Zhiwei Huang3

  • 1Huanghuai University Industry Innovation & Research and Development Institute, Huanghuai University, Zhumadian, Henan, China.

Archiv Der Pharmazie
|December 31, 2024
PubMed

Insights

Novel 1,2,3-triazole hybrids show promise for cancer treatment by overcoming drug resistance and reducing side effects. These compounds offer new therapeutic strategies against cancer.

Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Cancer remains a leading global cause of death, necessitating new treatments.
  • Chemotherapy faces challenges like multidrug resistance and severe side effects.
  • 1,2,3-triazole derivatives offer a promising scaffold for novel anticancer agents.

Purpose of the Study:

  • To review recent advancements in 1,2,3-triazole-heteroaromatic hybrids for cancer therapy.
  • To explore their mechanisms of action, design principles, and structure-activity relationships (SARs).
  • To highlight their potential in developing innovative cancer treatments.

Main Methods:

  • Literature review of articles published from 2021 to the present.
  • Focus on 1,2,3-triazole fused with six-membered nitrogen-containing heteroaromatic rings.
  • Analysis of anticancer therapeutic potential, mechanisms, design, and SARs.

Main Results:

  • 1,2,3-triazole hybrids, including quinazoline, quinolinone, and pyridine derivatives, exhibit significant anticancer activity.
  • These hybrids can target multiple cellular components simultaneously.
  • Click chemistry facilitates the synthesis of these versatile anticancer pharmacophores.

Conclusions:

  • 1,2,3-triazole-based hybrids represent a valuable class of compounds for cancer drug discovery.
  • Their unique structure allows for diverse interactions with cancer cell targets.
  • Further research into these hybrids could lead to more effective cancer therapies.
Keywords:
1,2,3‐triazolecancerhybridsmechanisms of actionstructure‐activity relationship

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