Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023
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View abstract on PubMed
Summary
This summary is machine-generated.Eight human influenza A virus (IAV) infections were detected in Brazil, linked to swine IAVs. Continuous surveillance is crucial to monitor these zoonotic viruses and assess potential human-to-human transmission risks.
Area Of Science
- Virology
- Epidemiology
- Public Health
Background
- Zoonotic influenza A viruses (IAVs) pose a public health risk, particularly through swine-human transmission.
- Close contact between swine and humans facilitates the emergence of novel IAV strains.
Purpose Of The Study
- To report and characterize human infections with influenza A virus variants in Paraná, Brazil.
- To analyze the genetic relationship between human and swine IAVs in the region.
Main Methods
- Detection and genomic sequencing of influenza A virus variants from human cases.
- Phylogenetic analysis to determine the relationship of human IAVs to swine IAV lineages.
Main Results
- Eight human IAV variant infections (6 mild, 2 severe, 1 death) were identified between 2020-2023.
- Sequenced viruses belonged to H1N1v, H1N2v, H3N2v, and H1v subtypes, closely related to Brazilian swine IAVs.
- Specific clades identified included pdm09 lineage, 1B.2.3, and a Brazilian H3 swine IAV clade (H3.1990.5.1).
Conclusions
- Human infections with swine-derived influenza A viruses occur in Brazil.
- While sustained human-to-human transmission is rare, the potential exists and warrants ongoing surveillance.
- Continuous influenza surveillance and risk assessment are essential for managing zoonotic IAV threats.
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