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Updated: May 5, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

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Published on: November 13, 2016

Peripheral contributions to resting state brain dynamics.

Sarah Bricault^1,2, Miranda Dawson¹, Jiyoung Lee³

¹Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, US.

Nature Communications

|December 31, 2024

Summary

This summary is machine-generated.

Resting brain activity is influenced by sensory inputs, not just intrinsic neural properties. This study shows peripheral sensory channels impact brain connectivity, even in the absence of stimuli, and are altered in a rat model of autism.

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Area of Science:

Neuroscience
Systems Neuroscience
Functional Neuroimaging

Background:

Resting-state brain activity is often assumed to reflect intrinsic neural properties.
However, the influence of extrinsic factors on these dynamics is not fully understood.

Purpose of the Study:

To investigate the contribution of peripheral sensory input to resting-state functional connectivity.
To examine how these contributions are altered in a rat model of autism.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to measure brain activity in unanesthetized, immobilized rats.
Perturbations of somatosensory input channels were performed to assess their impact on resting-state correlations.
A rat model of autism was used to study alterations in functional connectivity.

Main Results:

Perturbing somatosensory inputs significantly altered functional connectivity between somatosensory areas and higher-order brain regions.
These resting-state effects were mediated by peripheral and thalamic structures involved in sensory processing.
Rats modeling autism exhibited reduced somatosensory functional connectivity and were less sensitive to vibrissa (whisker) inactivation.

Conclusions:

Resting-state brain activity is significantly influenced by extrinsic peripheral inputs, challenging the notion of purely intrinsic dynamics.
These findings highlight the role of sensory influences on brain phenotypes in both typical and atypical development, with implications for understanding neurological disorders.