Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

365
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
365
Long-term Potentiation01:35

Long-term Potentiation

54.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.8K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

1.4K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.4K
Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

1.4K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis....
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Learning shapes neural geometry in the primate prefrontal cortex.

Nature neuroscience·2026
Same author

Distinct roles of cortical layer 5 subtypes in associative learning.

Nature communications·2026
Same author

Granule cells reorient cortical manifolds to separate contexts but preserve their geometry.

bioRxiv : the preprint server for biology·2026
Same author

Hippocampus supports multi-task reinforcement learning under partial observability.

Nature communications·2025
Same author

Author Correction: Self-supervised predictive learning accounts for cortical layer-specificity.

Nature communications·2025
Same author

Correction: Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning.

eLife·2025

Related Experiment Video

Updated: Jun 4, 2025

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats
08:59

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

10.3K

Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation.

Joseph Pemberton1,2,3, Paul Chadderton4, Rui Ponte Costa5,6

  • 1Computational Neuroscience Unit, Intelligent Systems Labs, Faculty of Engineering, University of Bristol, Bristol, UK. jpmbrton@uw.edu.

Nature Communications
|December 31, 2024
PubMed
Summary

The brain uses cortico-cerebellar loops for rapid learning and adaptation. These brain circuits help acquire, switch, and consolidate tasks by predicting outcomes and maintaining cognitive dynamics.

More Related Videos

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

20.9K
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.5K

Related Experiment Videos

Last Updated: Jun 4, 2025

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats
08:59

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

10.3K
Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

20.9K
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.5K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cognitive Science

Background:

  • The brain needs to balance stability and adaptability for effective environmental interaction.
  • Mechanisms underlying this balance, particularly involving the cerebellum and cortex, remain largely unknown.

Purpose of the Study:

  • To investigate the role of cortico-cerebellar loops in brain's world model stability and environmental adaptation.
  • To propose and test a computational model of cerebellar function in cortical processing.

Main Methods:

  • Development of a computational model of cerebellar networks predicting cortical task-outcome.
  • Simulation of sensorimotor tasks to assess cerebellar feedback's impact on learning and switching.
  • Application of working memory tasks to evaluate the cerebellum's role in maintaining cognitive dynamics.

Main Results:

  • Cerebellar feedback facilitates rapid task acquisition and switching with stable cortical networks.
  • The cerebellum supports the maintenance of cognitive-specific dynamics in the cortex during working memory tasks.
  • Model simulations explain observed optogenetic and behavioral data.

Conclusions:

  • Cortico-cerebellar loops are crucial for rapid task acquisition, switching, and consolidation.
  • A systems consolidation theory is proposed, where task information transfers from cerebellum to cortex.
  • The findings highlight the cerebellum's role beyond motor control, extending to cognitive functions.