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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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DNA Microarrays02:34

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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The Central Dogma01:20

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Related Experiment Video

Updated: Jun 4, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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The Theranostic Genome.

Xiaoying Xu1, Pablo Jané2,3, Vincent Taelman1

  • 1University of Lucerne, Lucerne, LU, Switzerland.

Nature Communications
|December 31, 2024
PubMed
Summary
This summary is machine-generated.

We introduce the Theranostic Genome, a novel resource connecting human genes with theranostic compounds for precision cancer medicine. This AI-driven approach identifies new targets and therapies to improve cancer diagnosis and treatment.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Precision Medicine

Background:

  • Theranostic drugs offer personalized treatment but face challenges in target identification and drug development.
  • Current methods for characterizing theranostic potential are limited, hindering precision medicine advancements.

Purpose of the Study:

  • To introduce the Theranostic Genome, a comprehensive resource linking human genes to theranostic compounds.
  • To overcome bottlenecks in theranostic drug development by identifying and tailoring targeted therapies for cancer subpopulations.

Main Methods:

  • A hybrid human-AI pipeline integrating data from PubMed, Gene Expression Omnibus, DisGeNET, The Cancer Genome Atlas, and NIH Molecular Imaging and Contrast Agent Database.
  • Deep learning algorithms were employed to cross-reference genomic data with known theranostic compounds.
  • RNA sequencing data from over 17,000 human tissues were analyzed to identify theranostic targets and lead compounds.

Main Results:

  • The Theranostic Genome successfully bridges individual genes in human cancers with corresponding theranostic compounds.
  • Identification of specific theranostic targets and lead compounds for diverse human cancers.
  • Enabling the tailoring of targeted theranostics to specific cancer patient subpopulations based on genomic profiles.

Conclusions:

  • The Theranostic Genome is a valuable resource for advancing precision cancer medicine.
  • This approach facilitates the development of novel targeted theranostics for improved cancer diagnosis, treatment, and monitoring.
  • The Theranostic Genome is expected to accelerate the clinical translation of theranostic strategies.