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Updated: Jun 4, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Factors affecting fatigue progression in multiple sclerosis patients.

Dima Machtoub1, Callie Fares2, Hassan Sinan3

  • 1Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Scientific Reports
|December 31, 2024
PubMed
Summary

Worsening fatigue in multiple sclerosis (MS) is linked to progressive MS subtypes, increased depression, and pain. Managing these factors may improve patient quality of life.

Keywords:
DepressionFatiguePainProgressive MSRelapse-remitting MS

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Area of Science:

  • Neurology
  • Clinical Research
  • Patient Outcomes

Background:

  • Fatigue is a primary disabling symptom in multiple sclerosis (MS).
  • Limited research exists on the longitudinal factors influencing fatigue progression in MS patients.
  • Understanding these determinants is crucial for improving patient care and quality of life.

Purpose of the Study:

  • To identify sociodemographic, behavioral, clinical characteristics, and therapeutic regimens correlated with worsening fatigue over time in MS patients.
  • To investigate factors associated with changes in fatigue levels in a cohort of MS patients.

Main Methods:

  • Retrospective chart review of 483 patients diagnosed with MS.
  • Primary outcome: change in Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit (November 2018 - November 2020).

Main Results:

  • Progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and fatigue medications were significantly associated with increased fatigue.
  • Age, sex, smoking, pain medications, disease-modifying therapies, BMI, relapses, visits, steroid courses, and comorbidities showed no significant association with fatigue progression.

Conclusions:

  • Specific clinical factors like progressive MS subtypes, depression, and pain significantly correlate with worsening fatigue.
  • Interventions targeting depression, pain, and medication management may be beneficial for MS patients experiencing fatigue.
  • Further research is needed to establish causal relationships and optimize fatigue management strategies in MS.