Therapeutic effects of resveratrol and β-carotene on L-arginine-induced acute pancreatitis through oxidative stress and inflammatory pathways in rats
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View abstract on PubMed
Summary
This summary is machine-generated.Resveratrol (RES) and beta-carotene (βC) show protective effects against acute pancreatitis (AP) in rats. These compounds reduce oxidative stress, inflammation, and apoptosis, with RES exhibiting slightly superior efficacy.
Area Of Science
- Biochemistry
- Pharmacology
- Cell Biology
Background
- Acute pancreatitis (AP) is a severe pancreatic inflammation with systemic effects.
- Oxidative stress, inflammation, and apoptosis are key pathological mechanisms in AP.
- L-arginine is a common agent used to induce experimental AP models.
Purpose Of The Study
- To evaluate the therapeutic effects of resveratrol (RES) and beta-carotene (βC) on L-arginine-induced acute pancreatitis in a rat model.
- To investigate the impact of RES and βC on oxidative stress, pancreatic islet integrity, inflammatory markers, and apoptotic pathways in AP.
Main Methods
- Establishment of an L-arginine-induced acute pancreatitis model in Sprague Dawley rats.
- Administration of resveratrol (20 mg/kg) and beta-carotene (50 mg/kg) to separate treatment groups.
- Assessment of oxidative stress markers (MDA, GSH), pancreatic islet morphology (immunohistochemistry), inflammatory gene expression (qPCR), and apoptotic markers (qPCR).
Main Results
- L-arginine-induced AP significantly increased oxidative stress (elevated MDA, reduced GSH) and pancreatic inflammation (upregulated NF-κB, TNF-α, IL-1β).
- AP led to reduced Langerhans islet size and altered apoptotic gene expression (increased Bax, Caspase-3; decreased Bcl-2).
- Both RES and βC treatments significantly ameliorated oxidative stress, preserved islet morphology, suppressed inflammatory gene expression, and modulated apoptotic pathways. RES showed a slightly greater effect.
Conclusions
- Resveratrol and beta-carotene demonstrate significant protective effects against L-arginine-induced acute pancreatitis in rats.
- These compounds mitigate AP by reducing oxidative stress, preserving pancreatic islet integrity, suppressing inflammation, and modulating apoptosis.
- Resveratrol may offer a slightly more potent therapeutic benefit for acute pancreatitis compared to beta-carotene.
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