Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients.

EBioMedicine·2018

Same author

Relationship between pre-exercise muscle stiffness and muscle damage induced by eccentric exercise.

European journal of sport science·2018

Same author

Deoxynivalenol decreased intestinal immune function related to NF-κB and TOR signalling in juvenile grass carp (Ctenopharyngodon idella).

Fish & shellfish immunology·2018

Same author

Hypermethylation of miR-338-3p and Impact of its Suppression on Cell Metastasis Through N-Cadherin Accumulation at the Cell -Cell Junction and Degradation of MMP in Gastric Cancer.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology·2018

Same author

Reference genes selection for quantitative gene expression studies in tea green leafhoppers, Empoasca onukii Matsuda.

PloS one·2018

Same author

Urinary phthalate metabolites in relation to childhood asthmatic and allergic symptoms in Shanghai.

Environment international·2018

Search research articles

Related Experiment Video

Updated: May 9, 2026

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer.

Shaopeng Zhang¹, Ximo Xu¹, Kundong Zhang^1,2

¹Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cancer Immunology, Immunotherapy : CII

|December 31, 2024

Summary

This summary is machine-generated.

Pancreatic cancer cells use lactate to promote M2d macrophage polarization, which hinders anti-tumor immunity. Targeting OAS3 reverses this, enhancing cancer treatments and restoring immune response.

Keywords:

Lactate M2d METTL3 OAS3 Pancreatic cancer

More Related Videos

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Related Experiment Videos

Last Updated: May 9, 2026

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Area of Science:

Immunology
Oncology
Molecular Biology

Background:

Tumor-associated macrophages (TAMs) drive immune escape in pancreatic cancer (PC).
Lactate influences macrophage polarization, but mechanisms are unclear.
M2d macrophages secrete IL-10 and VEGF-A, suppressing CD8+ T cells and promoting angiogenesis.

Purpose of the Study:

Investigate lactate's role in PC-driven macrophage polarization.
Identify key regulators of M2d polarization in PC.
Evaluate OAS3 as a therapeutic target for PC.

Main Methods:

Analysis of PC cells and patient samples.
Investigated lactate/METTL3/OAS3 signaling axis.
Utilized humanized mouse models with OAS3-deficient macrophages.

Main Results:

PC cells induce M2d polarization via lactate, increasing IL-10 and VEGF-A.
OAS3 is upregulated by PCs through the lactate/METTL3/OAS3 axis.
OAS3 deficiency impairs M2d polarization and enhances gemcitabine/anti-PD-L1 efficacy.

Conclusions:

OAS3 is crucial for M2d polarization and pro-tumor functions in PC.
Targeting OAS3 can reverse M2d infiltration and restore anti-tumor immunity.
OAS3 represents a potential therapeutic target for pancreatic cancer.