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Association between constipation and incident chronic kidney disease in the UK Biobank study
Kipyo Kim1, Won-Hee Cho1, Seun Deuk Hwang1
1Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, 27 Inhangro, Jung-gu, Incheon, 22332, Republic of Korea.
Scientific Reports
|December 31, 2024
Summary
Constipation increases the risk of developing chronic kidney disease (CKD). This study found constipation is an independent risk factor for CKD, regardless of laxative use.
Area of Science:
- Nephrology
- Gastroenterology
- Epidemiology
Background:
- Previous studies suggest a link between constipation and chronic kidney disease (CKD).
- The impact of constipation on incident CKD and the role of laxatives are not fully understood.
Purpose of the Study:
- To investigate the association between constipation and the development of incident CKD.
- To explore the potential moderating effect of laxative use on this association.
Main Methods:
- Analysis of longitudinal UK Biobank data including hospital and general practice records.
- Cox proportional hazard models used to assess the risk of incident CKD in relation to constipation.
- Constipation defined by diagnostic codes or self-reported regular laxative use.
Main Results:
- Constipation was significantly associated with an increased risk of developing CKD (HR 1.51 for ICD-defined; HR 1.34 for ICD or laxative use).
- Individuals with constipation, even those using laxatives, showed a higher risk of incident CKD.
- Laxative use did not significantly moderate the association between constipation and incident CKD.
Conclusions:
- Constipation is an independent risk factor for incident CKD in a large population-based cohort.
- Findings suggest constipation may serve as a predictor for CKD development.
- Further research is needed to clarify the role of laxatives in controlled settings.
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