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Updated: May 7, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Published on: October 25, 2024

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The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S Prado1,2, Richard T Cattley1,2, Andreza B Sonego1,2

  • 1Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

The Journal of Experimental Medicine
|December 31, 2024
PubMed
Summary

PIKFYVE, a lipid kinase, is crucial for T helper 17 (Th17) cell differentiation and autoimmune disease development. Inhibiting PIKFYVE reduces Th17 cell activity and associated pathology, suggesting it as a therapeutic target.

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