Related Experiment Video
Updated: May 7, 2025
09:12
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Published on: May 11, 2018
6.8K
Engineering and Bio/Nanotechnological Applications of Virus Particles
Mauricio G Mateu1, Alejandro Valbuena2
1Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), and Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain. mgarcia@cbm.csic.es.
Sub-Cellular Biochemistry
|December 31, 2024
Summary
Engineered virus particles (VPs) offer versatile nanomachine applications. Genetic and chemical modifications enhance natural VPs for advanced uses in medicine, biotechnology, and nanotechnology.
Area of Science:
- Biotechnology
- Nanotechnology
- Biomedical Engineering
Background:
- Virus particles (VPs) are natural nanomachines with unique properties.
- Natural VPs require modification for specific biomedical and technological applications.
Purpose of the Study:
- To provide an overview of methods for obtaining and modifying virus particles.
- To review current and emerging applications of engineered VPs.
Main Methods:
- Overview of techniques for virion and viral capsid acquisition.
- Description of genetic and chemical engineering strategies for VP modification.
Main Results:
- Engineered VPs can be tailored for diverse applications.
- Current and developing uses span biomedicine, biotechnology, and nanotechnology.
Conclusions:
- Engineered VPs serve as valuable tools, materials, reagents, and nanodevices.
- VP engineering unlocks potential in advanced scientific and technological fields.
Keywords:
CapsidChemical functionalizationConfined reactionsDiagnostic imagingDirected evolutionGene therapyGenetic modificationInorganic nanoparticlesNanobiosensorsNanoparticleNanoscale materialsSite-directed mutagenesisTargeted drug deliveryVirionVirotherapyVirusVirus engineeringVirus particleVirus-like particle
