Early improvement of left ventricular dyssynchrony after percutaneous coronary intervention in patients with single

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Yanci Liu1, Shaoping Wang1, Hongyu Peng1

  • 1Department of Cardiology, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, No 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Heart and Vessels
|December 31, 2024
PubMed

Insights

Percutaneous coronary intervention for chronic total occlusion significantly reduces left ventricular dyssynchrony and improves ejection fraction, especially in patients without prior heart attacks. This suggests a proactive revascularization strategy may benefit these patients.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Imaging

Background:

  • The impact of percutaneous coronary intervention (PCI) on chronic total occlusion (CTO) on left ventricular dyssynchrony remains unclear.
  • Left ventricular dyssynchrony is a significant factor in cardiac function and patient outcomes.

Purpose of the Study:

  • To evaluate the effect of successful CTO PCI on left ventricular dyssynchrony.
  • To identify factors associated with dyssynchrony reduction and its relationship with ejection fraction improvement.

Main Methods:

  • Prospective study including 91 patients with one CTO vessel.
  • Tissue Doppler imaging (TDI) assessed left ventricular dyssynchrony index (DI) before and after CTO PCI.
  • Multiple regression analysis identified correlates of DI reduction.

Main Results:

  • Successful CTO PCI significantly reduced left ventricular DI (69.58 to 43.38, P < 0.001).
  • Higher initial DI correlated with greater DI reduction (Coef., -0.38; P < 0.001).
  • DI reduction was associated with ejection fraction (EF) improvement (Coef., -1.45; P = 0.01).

Conclusions:

  • CTO PCI effectively reduces left ventricular dyssynchrony and improves EF.
  • Patients without myocardial infarction and with severe dyssynchrony may benefit most from proactive revascularization.
  • Further research is needed to explore long-term benefits of CTO PCI-induced dyssynchrony reduction.

Keywords:
Chronic total occlusionDyssynchronyEchocardiographyPercutaneous coronary intervention

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