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Outcomes of Laparoscopic Radical Hysterectomy in Ia1-Ib1 Cervical Cancer Patients: A Multi-Center Study with 10 Years' Experiences in the Real World

  • 0Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central, South University/Hunan Cancer Hospital, Changsha, People's Republic of China.
Annals of Surgical Oncology +

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December 31, 2024

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December 31, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Laparoscopic radical hysterectomy (LRH) shows comparable survival outcomes to open abdominal radical hysterectomy (OARH) for low-risk cervical cancer (CC). Preoperative MRI can guide surgical approach selection for early-stage CC patients.

Area Of Science

  • Gynecologic Oncology
  • Minimally Invasive Surgery
  • Surgical Outcomes Research

Background

  • Cervical cancer (CC) staging and risk stratification are crucial for treatment planning.
  • Laparoscopic radical hysterectomy (LRH) is an alternative to open abdominal radical hysterectomy (OARH).
  • Evaluating LRH outcomes in low-risk early-stage CC is essential.

Purpose Of The Study

  • To compare survival outcomes of LRH versus OARH in International Federation of Gynecology and Obstetrics (FIGO) 2018 stage IA1-IB1 low-risk cervical cancer.
  • To assess the feasibility of selecting surgical approach based on preoperative imaging.

Main Methods

  • Retrospective analysis of 2010-2020 data from three hospitals.
  • Stratification of cervical cancer patients into low-risk and high-risk groups.
  • Kaplan-Meier analysis to compare 5-year overall survival (OS) and progression-free survival (PFS) between LRH and OARH.

Main Results

  • In low-risk CC, LRH demonstrated equivalent 5-year OS (98.6% vs 99.3%) and PFS (97.6% vs 98.4%) compared to OARH.
  • No significant survival differences were observed between LRH and OARH in low-risk CC, irrespective of lymphovascular space invasion (LVSI).
  • In high-risk CC, LRH showed significantly lower 5-year OS (91.3% vs 94.8%) and PFS (84.0% vs 88.8%) than OARH.

Conclusions

  • LRH is a viable surgical option with comparable survival to OARH for low-risk, early-stage cervical cancer (FIGO IA1-IB1).
  • Preoperative enhanced MRI and DWI MRI can guide the selection of the appropriate surgical approach.
  • This approach is clinically feasible for optimizing treatment in early-stage CC.

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