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Human Papilloma Virus Infection and Sinonasal Inverted Papilloma Recurrence: A Meta-Analysis.

Fayssal Alqudrah¹, Sharwani Kota¹, Jason Morgan¹

¹Department of Otolaryngology-Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

|December 31, 2024

Summary

Human papillomavirus (HPV) infection may increase the risk of sinonasal inverted papilloma (SNIP) recurrence. This association appears independent of HPV subtype, though further research is needed due to study variability.

Keywords:

human papillomavirus inverted papilloma meta‐analysis recurrence sinonasal tumor

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Published on: March 11, 2014

Area of Science:

Otolaryngology
Oncology
Virology

Background:

Sinonasal inverted papilloma (SNIP) is a benign tumor with a significant recurrence rate.
The role of human papillomavirus (HPV) infection in SNIP recurrence remains controversial.
Previous studies have yielded conflicting results regarding the association between HPV and SNIP recurrence.

Purpose of the Study:

To systematically review and meta-analyze existing literature to clarify the association between HPV infection and SNIP recurrence.
To determine the pooled odds ratio (OR) for recurrence in HPV-positive versus HPV-negative SNIP.
To investigate if HPV subtype (low-risk vs. high-risk) influences SNIP recurrence risk.

Main Methods:

A systematic search of PubMed, Embase, and Scopus databases was conducted.
Included case-control studies reporting SNIP recurrence and HPV status determined by PCR and ISH.
Meta-analysis was performed to calculate pooled ORs and 95% confidence intervals (CIs).

Main Results:

Twenty-five studies comprising 1116 benign SNIP tumors were analyzed.
HPV-positive SNIP demonstrated a pooled OR of 2.05 (95% CI: 1.31-3.19) for recurrence compared to HPV-negative tumors.
The increased risk of recurrence associated with HPV was not statistically significant between low-risk and high-risk HPV subtypes.

Conclusions:

HPV infection is associated with an increased risk of SNIP recurrence.
This increased risk appears independent of HPV subtype.
Variability in recent studies necessitates further investigation into the HPV-SNIP recurrence relationship.