Pregnancy with Wilson's Disease: A Case Series

Area of Science:

• * Medical Genetics
• * Hepatology
• * Maternal-Fetal Medicine

Background:

• * Wilson's disease is an autosomal recessive disorder impacting copper transport, leading to copper accumulation in organs like the liver, brain, and cornea.
• * This deposition results in hepatic (cirrhosis, liver failure) and neuropsychiatric manifestations, alongside reproductive issues such as menstrual cycle disorders and subfertility.
• * Pregnancy in women with Wilson's disease carries risks including preeclampsia, fetal growth restriction, and fetal neurological damage, especially with decompensated liver cirrhosis.

Observation:

• * Four cases of Wilson's disease patients experiencing successful pregnancy outcomes are presented.
• * Management strategies for pregnant women diagnosed with Wilson's disease were discussed.
• * The study highlights the potential for successful pregnancies following effective copper reduction therapy.

Findings:

• * Effective decoppering therapy can potentially restore the ovulatory cycle, facilitating pregnancy in women with Wilson's disease.
• * The cases demonstrate that pregnant women with Wilson's disease can achieve successful pregnancy outcomes with appropriate medical management.
• * Management of pregnancy in Wilson's disease requires careful consideration of maternal and fetal well-being.

Implications:

• * This research underscores the importance of multidisciplinary care for pregnant women with Wilson's disease.
• * Successful management can mitigate risks associated with Wilson's disease during pregnancy, improving maternal and fetal outcomes.
• * Further research into optimal therapeutic strategies for Wilson's disease during pregnancy is warranted.