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Updated: May 5, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Association Between Lipoprotein(a) and Dilatation of Different Aortic Segments in Hypertensive Patients

Lin Wang1, Chaoqun Ma2, Xiaowei Liu1

  • 1Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, China.

Echocardiography (Mount Kisco, N.Y.)
|December 31, 2024
PubMed

Insights

Elevated lipoprotein(a) levels are linked to aortic root dilatation in hypertensive patients. This study identifies Lp(a) as an independent predictor of aortic root dimensions, particularly in individuals with hypertension.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Hypertension Research

Background:

  • Limited research exists on the association between lipoprotein(a) [Lp(a)] and aortic root dimensions (ARDMs).
  • Hypertension is a significant risk factor for cardiovascular diseases, potentially influencing ARDMs.

Purpose of the Study:

  • To investigate the relationship between Lp(a) levels and ARDMs in hypertensive patients.
  • To determine if Lp(a) is an independent predictor of aortic root dilatation.

Main Methods:

  • Echocardiography was used to measure ARDMs (aortic valve annulus, sinuses of Valsalva, sinotubular junction, ascending aorta) in 513 hospitalized patients.
  • Lp(a) levels and other laboratory parameters were analyzed.
  • Statistical analysis, including regression and restricted cubic spline analysis, was performed.

Main Results:

  • Lp(a) showed a positive and independent association with the diameter of the sinuses of Valsalva (SV) and sinotubular junction (STJ) in hypertensive patients.
  • Elevated Lp(a) levels were independently associated with SV dilatation (SVD) and ascending aorta dilatation (AAD) in hypertensive individuals.
  • Subgroup analysis revealed significant associations between Lp(a) and SVD across all groups, and with AAD in males and younger patients (≤65 years).

Conclusions:

  • Elevated Lp(a) concentrations are intricately linked to ARDMs at the SV and STJ in hypertensive patients.
  • Lp(a) serves as a standalone indicator for SVD and AAD in this population.
  • Further research may explore Lp(a) as a therapeutic target for preventing aortic root dilatation in hypertensive individuals.
Abstract

Keywords:
aortic root dilatationcardiovascular diseaseechocardiographyhypertensionlipoprotein(a)

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