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Updated: Jun 4, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Applying recommendations for diagnostic disclosure of mild cognitive impairment and dementia: Practical guidance for
Kyra O'Brien1, Emily A Largent2, Jason Karlawish1,2,3
1Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Abstract:
A comprehensive evaluation for cognitive impairment should culminate with the communication of the diagnosis to patients and their care partners. This diagnostic disclosure sets the stage for subsequent care. Diagnostic disclosure for individuals with cognitive impairment due to Alzheimer's disease (AD) or AD-related dementias (ADRD) is particularly nuanced and requires a conscientious approach. Clinicians must assess patients' understanding and appreciation of symptoms, goals for the evaluation, and desire for information. Because AD/ADRD can impact patients' perceptions of their symptoms, it is recommended to include an informant or care partner for this assessment and for future care. Here, we provide guidance for addressing the complexities of AD/ADRD diagnostic disclosure to build clinicians' confidence in communicating diagnostic findings and a plan of care. HIGHLIGHTS: Diagnostic disclosure is a key part of the evaluation of cognitive impairment. The disclosure process begins at the moment a cognitive evaluation is initiated. Care partners must be included in the cognitive evaluation and diagnostic disclosure. Clinicians should use patient-centered communication for evaluation and disclosure.
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