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Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal

Guillermo Gonzalez-Burgos1, Takeaki Miyamae1, Yosuke Nishihata1

  • 1Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

Journal of Neurophysiology
|December 31, 2024
PubMed

Keywords:
EPSCIPSCKir2.1 channelsnonhuman primateprefrontal cortex

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...