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Updated: Jul 26, 2026

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 3. Aerobiology
Published on: October 3, 2016
Airborne transmission of measles in a physician's office
Abstract:
An unusual outbreak of measles occurred in 1982 in a pediatrician's office in Muskegon, Mich. Three children, who had arrived at the office 60 to 75 minutes after a child with measles had departed, developed measles. Using a model based on airborne transmission, it is estimated that the index patient was producing 144 units of infection (quanta) per minute while in the office. Characteristics such as coughing, increased warm air recirculation, and low relative humidity may have increased the likelihood of transmission. Adequate immunization of all patients and staff, respiratory isolation and prompt care of all suspected cases, and adequate fresh-air ventilation should decrease the risk of airborne transmission of measles in this setting. Airborne transmission may occur more often than previously suspected, a possibility that should be considered when evaluating current measles control strategies.
Insights
Measles can spread through the air long after an infected person leaves a room. This airborne transmission highlights the need for better ventilation and isolation protocols in healthcare settings to prevent outbreaks.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Measles outbreaks can occur in healthcare settings.
- Airborne transmission of infectious agents is a significant concern.
- Previous understanding of measles transmission dynamics may be incomplete.
Purpose of the Study:
- To investigate an unusual measles outbreak in a pediatrician's office.
- To estimate the airborne infectious potential of a measles case.
- To assess factors influencing measles transmission in a clinical environment.
Main Methods:
- Analysis of a measles outbreak in a pediatrician's office.
- Application of an airborne transmission model.
- Estimation of infectious quanta production per minute.
Main Results:
- Three measles cases occurred 60-75 minutes after the index patient's departure.
- The index patient was estimated to produce 144 quanta per minute.
- Coughing, air recirculation, and low humidity may have facilitated transmission.
Conclusions:
- Airborne measles transmission can occur over extended periods post-exposure.
- Healthcare facilities must consider enhanced ventilation and isolation for measles control.
- Current measles control strategies may need re-evaluation in light of airborne transmission potential.
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