Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

83
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
83
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

141
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
141
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

96
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
96
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

97
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
97
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

93
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
93
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

100
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
100

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potassium <i>tert</i>-Butoxide-Mediated Isomerization of Alkenes: A Versatile Protocol for Miscellaneous Substrates.

ACS omega·2026
Same author

Phthalimide Derivatives as Anti-Inflammatory Agents: In Silico COX-2 Targeting and In Vitro Inhibition of PGE<sub>2</sub> Production.

Pharmaceutics·2026
Same author

Four-Step Synthesis of 3-Allyl-2-(allyloxy)-5-bromoaniline from 2-Allylphenol.

Molbank·2025
Same author

Catalyst to cure: applications of a new copper-based nanocatalyst in organic synthesis and cancer treatment.

Chemical communications (Cambridge, England)·2024
Same author

Aqueous Extracts of <i>Rhus trilobata</i> Inhibit the Lipopolysaccharide-Induced Inflammatory Response In Vitro and In Vivo.

Plants (Basel, Switzerland)·2024
Same author

Production and Physicochemical Characterization of the Gel Obtained in the Fermentation Process of Blue Corn Flour (<i>Zea mays</i> L.) with <i>Colletotrichum gloeosporioides</i>.

Gels (Basel, Switzerland)·2024
Same journal

Indole-based carbohydrazides as potent anti-proliferative leads and tubulin polymerization inhibitors: design, synthesis, cytotoxic evaluation, <i>in silico</i> ADMET and docking studies.

Future medicinal chemistry·2026
Same journal

Recent advances in the development of small molecule STK33 inhibitors.

Future medicinal chemistry·2026
Same journal

Biological evaluation and molecular docking of previously reported pyrazolo-thiazole derivatives as dual α-amylase and α-glucosidase inhibitors.

Future medicinal chemistry·2026
Same journal

Coumarin derivatives as antidiabetic agents: a comprehensive review on mechanistic insights, structure-activity relationships, <i>in silico</i> studies, and challenges.

Future medicinal chemistry·2026
Same journal

Expanding the tetrazole space: medicinal chemistry, biological diversity and structure-activity relationships.

Future medicinal chemistry·2026
Same journal

Thiazolidin-based dual Aurora kinase inhibitors with potent anticancer activity.

Future medicinal chemistry·2026
See all related articles

Related Experiment Video

Updated: May 7, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

9.6K

Phthalimides as anti-inflammatory agents.

Hector Mario Heras Martinez1,2, Enrique Barragan1, Kostiantyn O Marichev3

  • 1Department of Chemistry & Physics, Florida Gulf Coast University, Fort Myers, FL, USA.

Future Medicinal Chemistry
|December 31, 2024
PubMed
Summary
This summary is machine-generated.

Phthalimide derivatives show significant anti-inflammatory and anticancer properties. This review highlights their synthesis and anti-inflammatory applications, focusing on promising drug candidates like LASSBio 468.

Keywords:
Phthalimideanti-inflammatorydockingedemamicesynthesis

More Related Videos

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production

Published on: June 2, 2023

1.6K
2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
06:02

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

10.3K

Related Experiment Videos

Last Updated: May 7, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

9.6K
Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production

Published on: June 2, 2023

1.6K
2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
06:02

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

10.3K

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Isoindoline-1,3-dione (phthalimide) derivatives are recognized as valuable pharmacophores.
  • Phthalimides exhibit significant biological activities, notably as anticancer and anti-inflammatory agents.
  • The structural versatility of phthalimides has led to the development of numerous drug candidates.

Purpose of the Study:

  • To review the synthetic methodologies for phthalimide derivatives.
  • To explore the anti-inflammatory activities of reported phthalimide compounds.
  • To highlight promising phthalimide-based drug candidates for therapeutic development.

Main Methods:

  • Review of traditional synthetic routes including reaction of phthalic anhydride with amines/anilines and Gabriel synthesis.
  • Analysis of literature data on the anti-inflammatory studies of various phthalimide derivatives.
  • Identification and discussion of key phthalimide derivatives with therapeutic potential.

Main Results:

  • Established synthetic protocols provide access to a diverse range of phthalimide structures.
  • Several phthalimide derivatives demonstrate potent anti-inflammatory effects.
  • Commercially available drugs (thalidomide, pomalidomide, lenalidomide) and novel compounds (LASSBio 468, adducts 2, 9, 150, 241, 255, 305) show therapeutic promise.

Conclusions:

  • Phthalimide derivatives represent a rich source of compounds with significant anti-inflammatory and anticancer potential.
  • Optimized synthetic strategies facilitate the exploration of novel phthalimide analogs.
  • Continued research into phthalimide derivatives is crucial for discovering new therapeutic agents.