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Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.

Ludwig G Bauer1,2, Jennifer A Ward1,2, Laura Díaz-Sáez1,2

  • 1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK.

Angewandte Chemie (International Ed. in English)
|December 31, 2024
PubMed
Summary

Histone methyltransferase inhibitors unexpectedly target choline kinase alpha (CHKA), a key regulator of cell metabolism. This discovery offers new avenues for developing CHKA inhibitors for cancer and immune research.

Keywords:
cell paintingchemical probeschemical proteomicsmetabolomicsphenotypic

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