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Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis

Bruna Couto1, Celestino Neves2,3,4, João Sérgio Neves3,5

  • 1Faculty of Medicine, University of Porto, Porto, Portugal. brunatcouto@gmail.com.

BMC Endocrine Disorders
|December 31, 2024
PubMed

Insights

Hashimoto's thyroiditis patients show complex links between cardiovascular risks, thyroid function, and thyroid size. Understanding these connections may help reduce heart disease risk in affected individuals.

Area of Science:

  • Endocrinology
  • Cardiology
  • Immunology

Background:

  • Hashimoto's thyroiditis (HT) is linked to increased cardiovascular disease (CVD) risk.
  • Thyroid volume exhibits significant variability in HT patients.
  • The relationship between thyroid autoimmunity, morphology, and CVD risk factors requires further clarification.

Purpose of the Study:

  • To investigate the associations between thyroid antibodies, thyroid morphology, insulin resistance, and lipid profiles in patients with HT.
  • To explore the interplay of these factors in the context of cardiovascular risk.

Main Methods:

  • A cross-sectional study involving 409 individuals diagnosed with HT.
  • Assessment of thyroid function, autoimmune markers, and cardiovascular risk indicators.
  • Thyroid ultrasound evaluation and correlation analysis of all measured factors.

Main Results:

  • Higher anti-thyroperoxidase antibodies (TPOab) levels were observed in hypothyroid patients.
  • A positive correlation was found between TPOab and thyroid volume.
  • Negative correlations were identified between thyroid-stimulating hormone (TSH) and thyroid volume.

Conclusions:

  • A complex interrelationship exists between CVD risk factors, thyroid function, autoimmunity, and thyroid volume in HT.
  • These findings suggest potential clinical relevance for managing cardiovascular risk in HT.
  • Further research is warranted to translate these associations into clinical practice for reducing CVD risk.
Abstract

Keywords:
AutoimmuneAutoimmunityHashimoto diseaseHeart disease risk factorsThyroiditis

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