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Antibodies Against Phosphorylcholine in Prediction of Cardiovascular Disease Among Women: A Population-Based

Johan Frostegård1, Agneta Åkesson1, Emilie Helte1

  • 1Units of Immunology and chronic disease, and Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

JACC. Advances
|January 1, 2025
PubMed

Insights

Antibodies against phosphorylcholine (anti-PC) show protective effects against cardiovascular disease (CVD) in women. Higher IgM anti-PC levels were linked to a significantly reduced risk of myocardial infarction (MI), suggesting a role in CVD prevention.

Area of Science:

  • Immunology
  • Cardiovascular Science
  • Epidemiology

Background:

  • Antibodies against phosphorylcholine (anti-PC) are linked to protection against atherosclerosis, cardiovascular disease (CVD), and chronic inflammatory conditions.
  • Potential mechanisms include anti-inflammatory effects, enhanced clearance of dead cells, and inhibition of oxidized low-density lipoprotein (oxLDL).

Purpose of the Study:

  • To investigate the association between IgM anti-PC levels and the incidence of CVD in women.
  • To explore sex-specific differences in the role of anti-PC in CVD risk, as less is known about women.

Main Methods:

  • Serum IgM anti-PC levels were measured in 932 women from the Swedish Mammography Cohort using Enzyme Linked Immunosorbent assay (ELISA).
  • Prospective associations with incident CVD, ischemic heart disease (IHD), myocardial infarction (MI), and ischemic stroke were analyzed using Cox proportional hazard regression.
  • Models were adjusted for potential confounding factors.

Main Results:

  • Over 16 years, 113 CVD cases, 69 IHD cases, 44 MI cases, and 50 ischemic stroke cases were identified.
  • IgM anti-PC showed a statistically significant inverse association with the risk of CVD, IHD, and MI.
  • The highest tertile of IgM anti-PC was associated with a multivariable-adjusted Hazard Ratio (HR) of 0.27 (95% CI: 0.11-0.68) for MI.

Conclusions:

  • Elevated IgM anti-PC levels may play a protective role in the development of CVD in women, particularly MI.
  • IgM anti-PC may serve as a potential biomarker for identifying women at increased risk of CVD.
Abstract

Keywords:
antibodiescardiovascular diseasemyocardial infarctionphosphorylcholinestroke

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