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Aminoglycoside/Hexadecanoic Acid Complex Lamellar Core Nanoparticles.

Ajay J Khopade1, Nitin Chitranshi2

  • 1Sun Pharma Advanced Research Centre, Nima Compound, Tandalja, Vadodara 390020, Gujarat, India.

ACS Omega
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Tobramycin sulfate (TbS) and hexadecanoic acid (HdA) formed stable lamellosomes, nano-sized drug carriers. These novel nanocarriers demonstrate potential for controlled drug release and multidrug delivery applications.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Aminoglycosides like tobramycin sulfate (TbS) are crucial antibiotics.
  • Developing effective drug delivery systems is essential for improving therapeutic outcomes.
  • Nanoparticle formulations offer potential for enhanced drug stability and targeted delivery.

Purpose of the Study:

  • To develop novel nanocarriers for tobramycin sulfate (TbS).
  • To characterize the nanostructure and stability of the developed particles.
  • To evaluate the potential of these nanocarriers for co-delivery of other drugs.

Main Methods:

  • Complexation of tobramycin sulfate (TbS) with hexadecanoic acid (HdA) to form a lamellar nanostructure.
  • Production of nanoparticles using poloxamer 188 as a dispersing agent.
  • Characterization of particle size, ζ-potential, and stability under varying conditions (NaCl concentration, pH).
  • Evaluation of dexamethasone loading and in vitro drug release.

Main Results:

  • Formation of stable, agglomerate-free lamellosomes (90-450 nm) with a TbS/HdA lamellar core and poloxamer shell.
  • Nanoparticles exhibited good stability in 0.2 mol/L NaCl but were sensitive to pH changes.
  • Successful loading of dexamethasone (up to ~2% w/w) without crystallization.
  • Significantly retarded release of the entrapped drug.

Conclusions:

  • TbS/HdA lamellosomes represent a promising nanocarrier system for aminoglycosides.
  • The developed lamellosomes can encapsulate additional drugs, indicating potential for multidrug cargo.
  • Steric effects and ionic charge contribute to nanoparticle stabilization, offering tunable properties for drug delivery.