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Updated: May 7, 2025

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
Published on: December 14, 2009
Biologically inspired microlens array camera for high-speed and high-sensitivity imaging
Hyun-Kyung Kim1,2, Young-Gil Cha1,2, Jae-Myeong Kwon1,2
1Department of Bio and Brain engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
Abstract:
Nocturnal and crepuscular fast-eyed insects often exploit multiple optical channels and temporal summation for fast and low-light imaging. Here, we report high-speed and high-sensitive microlens array camera (HS-MAC), inspired by multiple optical channels and temporal summation for insect vision. HS-MAC features cross-talk-free offset microlens arrays on a single rolling shutter CMOS image sensor and performs high-speed and high-sensitivity imaging by using channel fragmentation, temporal summation, and compressive frame reconstruction. The experimental results demonstrate that HS-MAC accurately measures the speed of a color disk rotating at 1950 rpm, recording fast sequences at 9120 fps with low noise equivalent irradiance (0.43 μW/cm2). Besides, HS-MAC visualizes the necking pinch-off of a pool fire flame in dim light conditions below one thousandth of a lux. The compact high-speed low-light camera can offer a distinct route for high-speed and low-light imaging in mobile, surveillance, and biomedical applications.

