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Updated: Jun 4, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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Natural products as Nrf2 modulators for ferroptosis inhibition in renal disease therapy: Recent progress and future

Ruimin Tian1, Shan Guo2, Shudong Chen2

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China; The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|January 1, 2025
PubMed
Abstract

Insights

Natural products that regulate Nrf2 (nuclear factor erythroid 2-related factor 2) can inhibit ferroptosis, offering protective effects against various renal diseases. This review highlights these natural products for potential kidney disease therapies.

Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology
  • Nephrology

Background:

  • Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular processes including redox balance and inflammation.
  • Nrf2 plays a critical role in ferroptosis and the pathogenesis of renal diseases.
  • A comprehensive overview of natural products targeting Nrf2-related ferroptosis in renal diseases is needed.

Purpose of the Study:

  • To review the therapeutic potential of natural products that modulate Nrf2-related ferroptosis in the context of renal diseases.
  • To consolidate current knowledge on the protective effects of these natural products against kidney conditions.

Main Methods:

  • Systematic literature search across major scientific databases (PubMed, Web of Science, Google Scholar, CNKI, Wanfang, VIP).
  • Keywords included Nrf2, ferroptosis, natural products, phytochemicals, and various renal disease terms.
  • Comprehensive exploration of research on Nrf2, ferroptosis, and natural product interventions in kidney diseases.

Main Results:

  • Ferroptosis is implicated in diverse renal diseases such as acute kidney injury, diabetic nephropathy, and renal fibrosis.
  • Nrf2 regulates genes involved in iron, antioxidant, and lipid metabolism, thereby influencing ferroptosis.
  • Over twenty natural products demonstrate renoprotective effects by inhibiting ferroptosis through Nrf2 modulation.

Conclusions:

  • Natural products acting as Nrf2 modulators offer therapeutic benefits by inhibiting ferroptosis in renal diseases.
  • This review provides insights for developing novel therapeutic strategies and drug discovery for kidney diseases.
  • Further research and development of natural products for renal disease treatment are warranted.
Keywords:
FerroptosisKidney diseaseNatural productsNrf2Renal disease

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