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Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight MALDI-TOF Mass Spectrometry
Published on: June 10, 2018
Tetraphenylmethane based three-dimensional conjugated microporous polymer as adsorbent for solid-phase extraction of
Luan Huang1, Xin Zhou2, Qingyun Chang1
1Department of Chemistry, College of Science, Hebei Agricultural University, Baoding 071001, China.
Abstract:
Sulfonamide antibiotics have a broad spectrum of antibacterial action and are widely used, but their overuse poses a threat to human health. In this study, a three-dimensional conjugated microporous polymer, which was designated as TPM-CMP, was synthesized via Friedel-Crafts reaction by using tetraphenylmethane (TPM) and biphenyl dichlorobenzene as monomers, and it was utilized as an adsorbent in solid-phase extraction (SPE) of sulfonamides. The TPM-CMP demonstrated high extraction efficiency for sulfonamides due to π-stacking interactions, hydrophobic forces, and pore-filling effects. Consequently, the SPE was combined with liquid chromatography to detect sulfonamides in milk samples. For this method established in this study, a good linear response was observed in the range of 3.3-300.0 ng g-1, with a detection limit (S/N = 3) between 1.0 and 1.5 ng g-1. The method recoveries of four sulfonamide in milk samples ranged from 83.4 % to 117 %, with relative standard deviations below 10 %.
Insights
A novel polymer adsorbent, TPM-CMP, effectively extracts sulfonamide antibiotics from milk using solid-phase extraction. This method offers sensitive and reliable detection of these crucial antimicrobial drugs.
Area of Science:
- Analytical Chemistry
- Materials Science
- Environmental Science
Background:
- Sulfonamide antibiotics are widely used but their overuse raises health concerns.
- Developing efficient methods for sulfonamide detection is crucial for food safety and public health.
Purpose of the Study:
- To synthesize a novel adsorbent material for sulfonamide extraction.
- To develop a sensitive solid-phase extraction (SPE) method coupled with liquid chromatography for sulfonamide detection in milk.
Main Methods:
- Synthesis of a three-dimensional conjugated microporous polymer (TPM-CMP) via Friedel-Crafts reaction.
- Application of TPM-CMP as an adsorbent in SPE for sulfonamides.
- Detection of sulfonamides using liquid chromatography.
Main Results:
- TPM-CMP exhibited high extraction efficiency for sulfonamides through π-stacking, hydrophobic interactions, and pore-filling.
- The developed SPE-LC method showed a good linear response (3.3-300.0 ng g⁻¹).
- Low detection limits (1.0-1.5 ng g⁻¹) and high recoveries (83.4%-117%) with low relative standard deviations (<10%) were achieved for sulfonamides in milk.
Conclusions:
- TPM-CMP is a promising adsorbent for sulfonamide solid-phase extraction.
- The developed SPE-LC method provides a sensitive and reliable approach for monitoring sulfonamides in milk samples.
- This advancement aids in ensuring food safety and mitigating risks associated with antibiotic overuse.
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