GC/MS analysis and green-synthesis of silver nanoparticles using Senna auriculata flower extract: Antibacterial,...

In the present state of nano drug research, the production of herbal nutritionally aided nanoparticles has a broad variety of applications of new non side effect medical medications, as long as they are founded with environmentally acceptable methods. Silver nanoparticles in the form of phytochemicals from traditional herbal remedies, specifically the flower of senna auriculata, have been produced. The green synthesized silver nanoparticles were subsequently characterized by UV-Visible spectroscopy, Transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and Thermo gravity analysis. In the current study on the green synthesis approach, one of the best candidates, Ag nanoparticles act as a potential agent to investigate the antibacterial activity by a well diffusion method. The green synthesized AgNPs had the highest significant antibacterial activity against Gram-negative bacteria E. coli at 100 μg/mL, as well as, the AgNPs exhibited great inhibitory effects on DPPH radicals and their antioxidant properties were favorably comparable to the antioxidant outcomes of ascorbic acid. Furthermore, at 100 μg/mL concentration, the S. auriculata silver nanoparticles showed substantial cytotoxic effects against human breast cancer MCF-7 cell lines when compared to their effect on the normal cell line tested. The GC-MS analysis of the S. auriculata extract showed that 55 bioactive phytochemical compounds, which may be of use to the synthesis of AgNPs. Hence, the green synthesized silver nanoparticles from flower extract S. auriculata can be employed for biomedical applications.