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The effect of resistance training and nandrolone decanoate administration on cardiac tissue in mice

  • 0School of Health Sciences, Ariel University, Israel.
Steroids +

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January 1, 2025

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January 1, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Resistance training (RT) and nandrolone decanoate (ND) increased cardiac inflammation and apoptosis markers. However, elevated adiponectin suggests a potential compensatory cardiovascular protective effect from RT and ND.

Area Of Science

  • Cardiovascular Physiology
  • Exercise Science
  • Pharmacology

Background

  • Cardiac tissue is susceptible to inflammatory, apoptotic, and oxidative stress.
  • Adiponectin is a potential cardio-protective adipokine.
  • Understanding the impact of resistance training and anabolic-androgenic steroids on cardiac health is crucial.

Purpose Of The Study

  • To investigate the effects of resistance training (RT) alone and combined with nandrolone decanoate (ND) on cardiac inflammatory, apoptotic, and oxidative stress markers.
  • To examine the influence of RT and ND on adiponectin expression in cardiac tissue.

Main Methods

  • Forty male C57Bl/6J mice were divided into four groups: sedentary (SED) and resistance training (RT), each with or without nandrolone decanoate (ND) administration.
  • The RT groups underwent a 7-week, 3-day/week resistance training program.
  • ND was administered weekly at 38 mg·kg⁻¹ to specific groups, while others received sham injections.

Main Results

  • Resistance training (RT) significantly increased nuclear factor-kappa B (NFκβ), glutathione peroxidase (GPX), and adiponectin levels.
  • Nandrolone decanoate (ND) administration elevated NFκβ and tumor necrosis factor-alpha (TNF-α) expression.
  • The combined RT and ND group (RTA) showed higher TNF-α and adiponectin expression compared to other groups.

Conclusions

  • Both resistance training (RT) and nandrolone decanoate (ND) administration can augment markers of cardiac apoptosis and inflammation.
  • Increased adiponectin expression in response to RT and ND may indicate a compensatory mechanism for cardiovascular protection.
  • A strong positive correlation exists between training volume and GPX expression, highlighting the dose-dependent effect of exercise.

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