Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Sounds01:15

Heart Sounds

1.8K
Heart sounds are generated by the turbulence in blood flow due to the closing of heart valves. These sounds are best perceived slightly away from the valves, where the blood flow disseminates the sound.
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V)...
1.8K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K
Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

100
Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
100
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

863
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
863
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

886
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
886

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in cardiac implantable electronic device infections: 2015 to 2019.

BMC cardiovascular disorders·2026
Same author

The Predictive Value of Impedance for Defibrillation Success After S-ICD Implantation: A Reliable Indicator?

JACC. Clinical electrophysiology·2026
Same author

Subcutaneous Defibrillator Implantation With or Without Defibrillation Test: The Primary Results of the Randomized PRAETORIAN-DFT Trial.

Circulation·2026
Same author

Delphi consensus recommendations for preventing and treating cardiac implantable electronic device infections beyond current guidelines.

Scientific reports·2026
Same author

AIDE<sub>long</sub>-acute illness and depression in elderly: sustained improvement after group psychotherapy in geriatric patients, a follow-up of longterm effects in a randomized controlled trial.

BMC geriatrics·2026
Same author

Transjugular Leadless Pacemaker Implantation in an Adolescent With Central Hypoventilation Syndrome: A Case Report.

Pacing and clinical electrophysiology : PACE·2026

Related Experiment Video

Updated: Jun 4, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K

Left bundle branch block-Innocent bystander, silent menace, or both.

Ernest W Lau1, Hendrik Bonnemeier2, Benito Baldauf3

  • 1Department of Cardiology, Royal Victoria Hospital, Belfast, United Kingdom.

Heart Rhythm
|January 1, 2025
PubMed
Summary
This summary is machine-generated.

Left bundle branch block (LBBB) causes heart failure over time. Cardiac resynchronization therapy (CRT) shows promise for LBBB patients, potentially improving outcomes and exploring new pacing strategies.

Keywords:
Cardiac resynchronization therapyCardiomyopathyCausalityConduction system pacingEpidemiologyHeart failure with preserved ejection fractionLeft bundle branch blockNatural historyReverse modeling

More Related Videos

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

256
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

3.0K

Related Experiment Videos

Last Updated: Jun 4, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K
Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

256
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

3.0K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Left bundle branch block (LBBB) induces left ventricular (LV) electrical and mechanical dyssynchrony, leading to progressive myocardial damage.
  • Initial LV ejection fraction (EF) reduction in LBBB is modest (≈55%) due to cardiac functional redundancy, delaying symptom onset.
  • Patients with LBBB may develop heart failure (HF), progressing from HF with preserved EF (HFpEF) to HF with reduced EF (HFrEF) over years.

Purpose of the Study:

  • To evaluate the potential of cardiac resynchronization therapy (CRT) in patients with LBBB, particularly those with HFpEF.
  • To explore emerging pacing strategies like left bundle branch area pacing for mitigating LBBB's adverse effects.
  • To highlight the underutilization of CRT in HFpEF with LBBB despite promising anecdotal evidence.

Main Methods:

  • Review of existing literature on LBBB, HF progression, and current CRT indications.
  • Analysis of randomized controlled trials demonstrating CRT benefits in HF with moderately reduced EF (HFmrEF) and LBBB.
  • Examination of anecdotal reports and potential for future clinical trials in HFpEF with LBBB.

Main Results:

  • LBBB significantly shortens survival in HFmrEF patients by approximately 5.5 years.
  • CRT has demonstrated improvements in echocardiographic indices for HFmrEF patients with LBBB.
  • Anecdotal evidence suggests CRT may alleviate symptoms in HFpEF patients with LBBB, a population representing about 6% of all HF patients.

Conclusions:

  • Cardiac resynchronization therapy (CRT) is a guideline-indicated therapy for HFrEF and LBBB, with proven benefits in HFmrEF.
  • CRT in HFpEF with LBBB is a promising area requiring further investigation and potential underused therapy.
  • Left bundle branch area pacing represents a novel strategy that may reverse or prevent LBBB-induced cardiac damage.