Noninvasive Optical Sensing of Aging and Diet Preferences Using Raman Spectroscopy

Effective dietary strategies and interventions for monitoring dietary exposures require accurate and noninvasive methods to understand how diet modulates health and risk of obesity; advances in technology are transforming the landscape and enabling more specific tailored approaches to nutritional guidance. This study explores the use of Raman spectroscopy (RS), a noninvasive and nondestructive analytical technique, to identify changes in the mice skin in response to constant dietary exposures. We found that RS is highly accurate to determine body composition as a result of habitual dietary patterns, specifically Vegan, Typical American, and Ketogenic diets, all very common in the US context. RS is based on major differences in the intensities of vibrational bands that originate from collagen. Moreover, RS could be used to predict folate deficiency and identify the sex of the animals. Finally, we found that RS could be used to track the chronological age of the mice. Considering the hand-held nature of the utilized spectrometer, one can expect that RS could be used to monitor and, consequently, personalize effects of diet on the body composition.