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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

1.9K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
1.9K

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Related Experiment Video

Updated: Jun 4, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

479

Parathyroid carcinoma: New insights.

Abhishek Viswanath1, Eftychia E Drakou2, Fannie Lajeunesse-Trempe3

  • 1Faculty of Life Sciences and Medicine, School of Life Course Sciences, King's College London, London, UK.

Best Practice & Research. Clinical Endocrinology & Metabolism
|January 1, 2025
PubMed
Summary

Recent advances in parathyroid carcinoma (PC) management include improved diagnostics like circulating tumor cells and advanced imaging. Emerging targeted therapies offer new hope for advanced disease.

Keywords:
hypercalcaemiahyperparathyroidismmalignancyparathyroid carcinoma

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Area of Science:

  • Endocrinology and Oncology
  • Rare Cancers Research

Background:

  • Parathyroid carcinoma (PC) is a rare malignancy, accounting for 1% of primary hyperparathyroidism (PHPT) cases.
  • Effective management strategies for PC are crucial due to its aggressive nature.

Purpose of the Study:

  • To review recent advancements in the diagnosis and management of parathyroid carcinoma.
  • To highlight molecular insights, diagnostic tools, surgical techniques, and targeted therapies.

Main Methods:

  • A narrative review of manuscripts published between 2023 and 2024.
  • Literature search conducted in PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL).

Main Results:

  • Diagnostic accuracy is improving with novel biochemical markers like circulating tumor cells (CTCs) and advanced imaging (18F-FDG PET/CT, 4D-CT).
  • Surgical resection remains the cornerstone for localized and metastatic PC.
  • Emerging targeted therapies including tyrosine kinase inhibitors (TKIs), temozolomide, and immune checkpoint inhibitors (ICIs) show potential for specific patient groups with advanced or unresectable disease.

Conclusions:

  • Continued research is needed to further improve outcomes for parathyroid carcinoma patients.
  • Management of advanced PC should be centralized in specialized centers of excellence for optimal care.