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RETRACTION: GANT61 Plays Antitumor Effects by Inducing Oxidative Stress through the miRNA-1286/RAB31 Axis in
Retraction:
K.-q. Zhang, X.-d. Chu, "GANT61 Plays Antitumor Effects by Inducing Oxidative Stress through the miRNA-1286/RAB31 Axis in Osteosarcoma," Cell Biology International 45, no. 1 (2020): 61-73, https://doi.org/10.1002/cbin.11467. The above article, published online on 16 September 2020, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Xuebiao Yao; and John Wiley & Sons Ltd. A third party notified the publisher that this article had reused images that had been used in multiple different publications, each by different sets of authors. Specifically, images from this article have been re-used from the following publications which had published before or near the same time: (Lei, et al. 2020 [https://doi.org/10.2147/OTT.S214514]); (Sun, et al. 2020 [https://doi.org/10.1002/cam4.2723]); (Hu, et al. 2020 [https://doi.org/10.2147/CMAR.S260693]); (Zhao, et al. 2020 [https://doi.org/10.21037/atm-20-5586]); (Ma, et al. 2020 [https://doi.org/10.21037/tcr.2020.04.13]); (Hong, et al. 2020 [https://doi.org/10.18632/aging.103278]); (Chen, et al. 2020 [https://doi.org/10.1002/cam4.2839]); (Wu, et al. 2019 [https://doi.org/10.3233/cbm-190534]); (Chen, et al. 2020 [https://doi.org/10.21037/tcr-20-940]); (Kang, et al. 2020 [https://doi.org/10.21037/tcr-20-1727]); (Wei, et al. 2020 [https://doi.org/10.2147/DDDT.S222694]); and (Xie, et al. 2020 [https://doi.org/10.21037/atm-20-7201]). In addition, images that appeared in this article have also been detected in the following subsequent publications: (Zhang & Song 2020 [https://doi.org/10.21037/atm-20-7253]); (Qiao, et al. 2021 [https://doi.org/10.1186/s12885-021-08730-7]); (Lv, et al. 2022 [https://doi.org/10.1080/13880209.2022.2032206]); (Yao, et al. 2022 [https://doi.org/10.1080/21655979.2022.2060776]); and (Zhou, et al. 2021 [https://doi.org/10.21037/atm-20-7365]). The authors did not respond to inquiries by the publisher. The retraction has been agreed to because the evidence of image duplications across different articles, each of which reports on different experimental conditions, fundamentally compromises the conclusions of this article. The authors did not respond to our notice regarding the retraction.
Insights
This study on GANT61 and osteosarcoma is retracted due to image reuse. The article "GANT61 Plays Antitumor Effects by Inducing Oxidative Stress through the miRNA-1286/RAB31 Axis in Osteosarcoma" is no longer valid.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- Osteosarcoma is a primary bone cancer with significant unmet therapeutic needs.
- Targeting specific molecular pathways, such as the miRNA-1286/RAB31 axis, is a key strategy in cancer research.
- Inducing oxidative stress is a proposed mechanism for achieving anti-cancer effects.
Purpose:
- To investigate the antitumor effects of GANT61 in osteosarcoma.
- To elucidate the role of the miRNA-1286/RAB31 axis in GANT61-mediated effects.
- To determine if GANT61 induces oxidative stress in osteosarcoma cells.
Summary:
- The article investigated GANT61's potential to combat osteosarcoma by inducing oxidative stress via the miRNA-1286/RAB31 pathway.
- Evidence of image duplication across multiple publications fundamentally compromises the integrity of the reported findings.
- The study has been retracted due to irreconcilable data integrity issues stemming from reused images.
Impact:
- The retraction of this study necessitates a re-evaluation of its purported findings on GANT61's efficacy in osteosarcoma.
- This case highlights the critical importance of rigorous image verification in scientific publishing to maintain research integrity.
- Future research should focus on independently validating any potential therapeutic roles of GANT61 in osteosarcoma.
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