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Covariate-adaptive biased coin randomization for master protocols with multiple interventions and

Tianhao Song1, Lisa M LaVange1, Anastasia Ivanova1

  • 1Department of Biostatistics, CB #7420, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7420, USA.

Statistics in Biopharmaceutical Research
|January 2, 2025
PubMed
Summary

This study introduces a biased coin design for clinical trials to improve intervention allocation. It ensures desired ratios of biomarker-positive and biomarker-negative participants are assigned to specific treatments.

Keywords:
Covariate-adaptive randomizationbiased coin designbiomarker-positive subgroupenrichment

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