High correlated color temperature white light-emitting diodes disrupt refractive development in guinea pigs

Ubiquitous white light-emitting diodes (LEDs) possess optical properties that differ from those of natural light. This difference can impact visual perception and biological functions, thus potentially affecting eye health. Myopia, which leads to visual impairments and potentially irreversible vision loss or blindness, is the most prevalent refractive error worldwide. Ambient light has been found to be a significant factor in refractive development. The overlap between the commonly utilized of white LEDs and the rapid increase in the prevalence of myopia raises suspicions that white LEDs may represent hidden visual cues. To clarify the potential effects of white LEDs on refractive development, we exposed guinea pigs to different forms of artificial lighting over a period of eight weeks. We found that exposure to white LEDs with a high correlated color temperature (CCT) of approximately 5000 K can induce significant myopic shifts in guinea pigs, along with a decrease in collagen accumulation in the sclera. Additionally, this exposure was found to significantly reduce choroidal tissue thickness in guinea pigs. Our study findings indicate that high CCT white LEDs disrupt refractive development in guinea pigs. These results suggest that high CCT white LEDs might similarly affect refractive development in humans, highlighting the need for further clinical investigation.