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Exploring the effect of carbon nanoparticle tracing technique on five-year overall survival and disease-free survival in patients undergoing radical surgery for colorectal cancer: a retrospective study

  • 0Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Oncology +

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January 2, 2025

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January 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative carbon nanoparticle tracing via colonoscopy increased lymph node detection in colorectal cancer surgery. However, this technique did not significantly improve 5-year survival or disease-free survival rates.

Area Of Science

  • Surgical Oncology
  • Gastroenterology
  • Medical Imaging

Background

  • Colorectal cancer (CRC) management involves radical resection.
  • Accurate lymph node assessment is crucial for staging and prognosis.
  • Minimally invasive techniques are explored to improve surgical outcomes.

Purpose Of The Study

  • To evaluate the impact of preoperative carbon nanoparticle tracing via colonoscopy on survival outcomes in CRC patients.
  • To determine if this technique influences 5-year overall survival (OS) and disease-free survival (DFS) rates.

Main Methods

  • Retrospective cohort study of 1,869 patients undergoing radical resection for CRC.
  • Comparison between patients who received carbon nanoparticle tracing (CAS group, n=758) and those who did not (non-CAS group, n=1,111).
  • Analysis of 5-year OS and DFS rates using survival curves and Cox regression models.

Main Results

  • The CAS group had a significantly higher number of detected lymph nodes (15 vs. 11, p<0.05).
  • 5-year OS rates were 90.8% (CAS) vs. 87.4% (non-CAS); 5-year DFS rates were 88.5% (CAS) vs. 83.4% (non-CAS).
  • Differences in OS and DFS between groups were not statistically significant (p>0.05).

Conclusions

  • Carbon nanoparticle tracing via colonoscopy enhances lymph node detection in CRC surgery.
  • The technique does not significantly improve 5-year overall survival or disease-free survival.
  • Independent factors influencing survival include age, tumor stage, and postoperative treatments.

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