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Updated: Jun 4, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Genotype-microbiome-metabolome associations in early childhood and their link to BMI
Andrea Aparicio1, Zheng Sun1, Diane R Gold1,2
1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Channing Division of Network Medicine Boston Massachusetts USA.
Abstract:
Through the analysis of data from children aged 6 months to 8 years enrolled in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), significant simultaneous associations were identified between variants in the fragile histidine triad (FHIT) gene, children's body mass index, microbiome features related to obesity, and key lipids and amino acids. These patterns represent evidence of the genotype influence in shaping the host microbiome in developing stages and new potential biomarkers for childhood obesity, insulin resistance, and type 2 diabetes.
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