Related Experiment Video
Updated: May 7, 2025
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis
Rou Deng1, Xiayu Cui2, Runze Zhang1
1Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abstract:
Sepsis is a systemic inflammatory response initiated by an infection, which can lead to multi-organ dysfunction. The pathophysiology of sepsis is complex, and treatment options are limited. Traditional antibiotic therapies have shown limitations, such as promoting the emergence of antibiotic-resistant bacteria and disrupting the natural microbiota. Consequently, there is a pressing need to explore diverse therapeutic approaches for sepsis management. Extracellular vesicles, which play a crucial role in cell-to-cell communication, are released by various cell types throughout the body and possess a membrane structure composed of a lipid bilayer. MicroRNAs may be encapsulated within these structures and can be selectively delivered to target recipient cells through the activation of cell surface receptors or via endocytosis and fusion, thereby modulating the biological functions of target cells. The article examines the pathological alterations that happen as sepsis progresses and the biological control of extracellular vesicles and microRNAs in sepsis. This review focuses on the role of extracellular vesicles and their microRNAs on controlling the inflammatory response, macrophage polarization, programmed cell death, endothelial dysfunction, and microcirculatory changes in sepsis. Furthermore, the obstacles encountered by this novel therapy are also examined.
Insights
Extracellular vesicles and microRNAs offer novel therapeutic potential for sepsis, a life-threatening condition. This review explores their role in managing inflammation, cell death, and organ dysfunction in sepsis.
Area of Science:
- Biomedical Science
- Molecular Biology
- Immunology
Background:
- Sepsis is a life-threatening systemic inflammatory response to infection, leading to multi-organ dysfunction.
- Current treatments, including antibiotics, face limitations like antibiotic resistance and microbiota disruption.
- Novel therapeutic strategies are urgently needed for effective sepsis management.
Purpose of the Study:
- To examine the role of extracellular vesicles (EVs) and microRNAs (miRNAs) in sepsis pathophysiology.
- To review the biological control mechanisms of EVs and miRNAs in sepsis progression.
- To explore the therapeutic potential of EVs and miRNAs in modulating sepsis-related processes.
Main Methods:
- Literature review focusing on the biological functions of EVs and miRNAs in sepsis.
- Analysis of pathological alterations during sepsis progression.
- Examination of the impact of EVs and miRNAs on key sepsis pathways.
Main Results:
- EVs and miRNAs are implicated in cell-to-cell communication and modulate biological functions in sepsis.
- These components influence inflammatory responses, macrophage polarization, programmed cell death, endothelial dysfunction, and microcirculatory changes.
- EVs and miRNAs demonstrate potential in controlling sepsis-induced pathological alterations.
Conclusions:
- Extracellular vesicles and microRNAs represent a promising novel therapeutic avenue for sepsis.
- Understanding their mechanisms can lead to advanced sepsis treatment strategies.
- Challenges associated with this novel therapy require further investigation.
More Related Videos
07:55Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections
Published on: November 8, 2024
07:03Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
