Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats

Excessive exercise can lead to fatigue, consequently affect exercise performance, and further have an adverse impact to human health. The synergistic effects of ginsenosides, salidroside, and syringin on improving exercise performance remain unknown. Hence, the effects of Chinese herb powder (CHP) which consisted of bioactive compounds such as ginsenosides (Rg1, Re, and Rb1), salidroside, and syringin on exercise performance, energy metabolism, tissue damage, antioxidant activity, and inflammatory cytokine were investigated in exhaustive exercise rats. Male Sprague-Dawley rats aged of 8-week-old were randomly assigned into four groups: control (normal, N), low-dose (L, 310 mg/kg bw), medium-dose (M, 620 mg/kg bw), and high-dose (H, 1550 mg/kg bw) groups. The intervention groups were orally given CHP daily for successive 30 days. Abdominal arterial blood, liver, and gastrocnemius muscles were collected 4 hours after exhaustive exercise for further analysis. The high-dose CHP group increased the time to exhaustion, decreased serum lactate level, increased serum superoxide dismutase activity, and decreased liver interleukin-6 concentration. Therefore, CHP exhibits an anti-fatigue effect for prolonging the time to exhaustion through improving lactate clearance, and to a lesser extent, enhancing the capacity of antioxidation and anti-inflammation.