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Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma
Domenico Albano1,2, Marco Ravanelli3, Rexhep Durmo4
1Nuclear Medicine Unit, ASST Spedali Civili of Brescia, Brescia, Italy.
Frontiers in Medicine
|January 2, 2025
Summary
Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[18F]-fluoro-D-glucose (2-[18F]FDG) offers valuable prognostic insights in lymphoma management. Semiquantitative parameters show promise but require standardization for clinical integration.
Area of Science:
- Nuclear medicine
- Oncology
- Radiology
Background:
- 2-deoxy-2-[18F]-fluoro-D-glucose (2-[18F]FDG) PET/CT is vital for lymphoma management, including staging, response assessment, and prognosis.
- Beyond visual analysis, semiquantitative parameters derived from PET/CT offer insights into disease characteristics like tumor burden and dissemination.
Purpose of the Study:
- To review the prognostic and predictive value of semiquantitative PET/CT parameters in lymphoma.
- To discuss the potential clinical applicability of these advanced PET-based biomarkers.
Main Methods:
- Review of studies investigating semiquantitative parameters in 2-[18F]FDG PET/CT for lymphoma.
- Analysis of parameters including body composition, disease dissemination (Dmax), tumor burden (metabolic tumor volume), and texture features.
Main Results:
- Semiquantitative parameters demonstrate promising results, particularly in predicting progression-free survival and overall survival in lymphoma patients.
- These parameters can reflect diverse disease characteristics, aiding in a comprehensive assessment.
Conclusions:
- While semiquantitative PET/CT parameters show significant prognostic value in lymphoma, a lack of standardization and shared methodology hinders widespread clinical adoption.
- Further prospective validation is necessary to overcome methodological limitations and integrate these advanced biomarkers into routine clinical decision-making.
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