Related Experiment Video
Updated: Jun 4, 2025
05:00
Author Spotlight: Enhancing Multicolor Fluorescence Localization in Lung Carcinoma Sample
Published on: November 21, 2023
1.6K
Tumor microenvironment in oral squamous cell carcinoma
Chenxi Li1, Xiaodan Dong1, Bo Li1
1Department of Oral Anatomy and Physiology, Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Hospital of Stomatology, Jilin University, Changchun, China.
Frontiers in Immunology
|January 2, 2025
Summary
Oral squamous cell carcinoma (OSCC) progression is driven by its tumor microenvironment (TME). This review explores how TME cells interact to influence OSCC, offering insights for new therapeutic strategies.
Area of Science:
- Oncology
- Cancer Biology
- Immunology
Background:
- Oral squamous cell carcinoma (OSCC) is an aggressive cancer with poor outcomes.
- Limitations in current therapies necessitate novel treatment approaches.
- The tumor microenvironment (TME) significantly influences OSCC initiation, development, and progression.
Purpose of the Study:
- To review the current literature on the role of cellular components within the TME in OSCC progression.
- To elucidate the complex interactions among various cells in the TME.
- To identify potential targets for novel OSCC therapeutic strategies.
Main Methods:
- Comprehensive literature review of studies investigating the OSCC tumor microenvironment.
- Analysis of the roles of key cellular components including macrophages, fibroblasts, lymphocytes, neutrophils, and dendritic cells.
- Examination of molecular mediators such as RNAs, proteins, cytokines, and metabolites involved in cell-cell communication within the TME.
Main Results:
- The TME comprises diverse cell types (TAMs, CAFs, T cells, TANs, MDSCs, DCs) that form a critical network.
- These cellular interactions modulate key cancer hallmarks: proliferation, invasion, migration, and angiogenesis.
- Secreted molecules (RNAs, proteins, cytokines, metabolites) mediate the functional outcomes of TME cellular crosstalk.
Conclusions:
- Understanding the intricate cellular network within the OSCC TME is crucial for advancing diagnosis and treatment.
- Targeting the complex cellular interactions and communication pathways in the TME offers promising avenues for novel therapeutic interventions.
- This review provides a foundation for developing innovative strategies against OSCC by leveraging TME modulation.
Related Concept Videos
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K