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Functionalized Microsphere Platform Combining Nutrient Restriction and Combination Therapy to Combat Bacterial
Qingjun Xu1, Yang Zhao1, Pingping Yuan1
1Animal-Derived Food Safety Innovation Team, College of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
ACS Applied Materials & Interfaces
|January 2, 2025
Summary
This study developed a novel drug delivery system using porous microspheres to combat multidrug-resistant bacteria. The system restricts bacterial iron intake and releases antibiotics, effectively clearing infections and offering a new strategy against resistant pathogens.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Drug Delivery Systems
Background:
- Multidrug-resistant (MDR) bacterial infections pose a significant global health threat, diminishing the effectiveness of current antibiotics.
- Novel strategies are urgently needed to overcome MDR pathogens and their resistance mechanisms.
Purpose of the Study:
- To develop and evaluate a multifunctional drug delivery system for enhanced efficacy against MDR bacteria.
- To integrate nutrient restriction (iron chelation) with combination antibiotic therapy for synergistic antimicrobial action.
Main Methods:
- Fabrication of core-shell porous poly(lactic-co-glycolic acid) (PLGA) microspheres coated with pH-responsive polydopamine (PDA).
- PDA coating was utilized for iron chelation to restrict bacterial nutrient availability.
- Porous PLGA core loaded with rifampicin and polymyxin B for controlled antibiotic release.
Main Results:
- The developed microsphere system effectively inhibited bacterial growth by chelating environmental iron ions.
- Combined iron restriction and antibiotic release (rifampicin and polymyxin B) led to rapid bacterial eradication.
- Demonstrated significant clearance (99% in 4 h) of Salmonella Typhimurium and improved outcomes in a murine intestinal infection model.
Conclusions:
- The multifunctional microsphere platform successfully integrates nutrient restriction and antibiotic killing for combating MDR bacteria.
- Targeting bacterial iron regulation presents a promising strategy for developing novel antimicrobial delivery systems.
- This approach offers a potential solution to the critical challenge of multidrug-resistant bacterial infections.
